Molecular Biophysics
Molecular biophysics is a vibrant, interdisciplinary research area, including investigations of macromolecular structure, function, and catalysis. A wide variety of approaches, including spectroscopy, X-ray crystallography, cryo-EM, microscopy, single molecule techniques, and computation are employed. Current research foci of the faculty include the structure, function, and evolution of nucleic acids; membranes, protein misfolding, and protein function; and cellular sensors and cellular/extracellular dynamics.
Faculty
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Natural Products; Genomics; Metagenomics; Biosynthesis; Enzymology; X-ray crystallography; Enzyme engineering; Chemical biology; Drug discovery
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Biophysics, Biochemistry, Chemical Biology, EPR spectroscopy, Raman spectroscopy, FT-IR spectroscopy, Photosynthesis, DNA synthesis, Proton coupled electron transfer, Redox signaling, Solar energy conversion, Biomimetics
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Biological imaging and spectroscopy; metal cluster fluorophores; fluorescent proteins; protein-protein interactions; novel imaging and spectroscopies; optically modulated fluorescence; statistics for multidimensional data analysis; antibacterial sensitivity; in vivo imaging
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bioinorganic chemistry; synthetic organic chemistry; coordination chemistry; organic photophysics; trace metal homeostasis; copper proteins; fluorescent probes; fluorescence imaging; x-ray fluorescence microscopy; live cell imaging; two-photon excitation microscopy
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molecular dynamics simulations; protein dynamics; membrane proteins; protein synthesis; bacteria-specific systems and processes
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Nucleic acids; chemical evolution; origin of life.
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Acid-β-glucosidase; Alzheimer; Amyloid; Aspartyl protease; Crystallization chaperones; Crystallography; Engineered antibody fragments; Gaucher disease; Intramembrane proteolysis; Lipid storage disorders; Membrane protein; Myocillin; Olfactomedin (OLF); Open angle glaucoma; Protein misfolding diseases; SER-CAT
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Metallo-biochemistry, Metallo-chemical biology, Redox biology
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Structure & function of eukaryotic membrane proteins; membrane protein complexes; biophysics; cryo-EM; electron crystallography; 2D crystallization; image processing; inflammation; cancer
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Quantum chemistry; intermolecular forces; theoretical chemistry; algorithms; modeling; machine learning and data generation; software development; high-performance computing
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Ribosome; translation; RNA; RNA World; RNA folding; RNA Structure, RNA electrostatics; Iron; DNA Structure; DNA-Protein interactions; DNA-drug interactions; Origin of Life; crystallography; x-ray diffraction; biochemistry; bioinformatics; biophysics
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Analytical Chemistry; Bio-analytical Chemistry, Mass spectrometry (MS), MS-based proteomics; HPLC; LC-MS; Protein post-translational modifications; Cell signaling; Cancer; Metabolism; Disease biomarker.
